AetherProtocols
A programmable wearable device for measuring individualized physiological state, correlated in real time with clinically observable behavior.
A wearable that measures physiological state, not events.
- Programmable wearable device using existing microneedle sensing technology.
- AetherProtocols, a mathematical system of equations, synchronizes to each patient's physiological baseline.
- Once synchronized, it reports sustained deviation of physiological state from the patient's individualized reference.
- Measurements integrate into the EHR and are presented to physicians or clinical study personnel for interpretation, as a Digital Health Technology.
AetherProtocols does not predict, diagnose, or treat disease. It measures physiological state deviation.
Bedside observation, formalized.
The framework's origin is unconventional. The Principal Investigator developed the core insight while providing four years of direct bedside care in psychiatric, dementia, end-of-life, and locked behavioral units.
Clinical observation
Repeated observation of coordinated physiological and behavioral change across acute clinical settings suggested that physiology and behavior were expressions of the same evolving biological system.
Formal training
Biochemistry, molecular biology, physiology, calculus, differential equations, and linear algebra, applied to translate that clinical observation into a computable mathematical framework.
Behavior is a measurable expression of state.
- AetherProtocols proposes that clinically observable behavioral manifestations are measurable expressions of an individual's underlying physiological state.
- Rather than treating physiological measurements and behavior as independent observations, the framework mathematically models their relationship as components of the same evolving biological system.
- Individualized hormonal state can represent that underlying physiological condition, allowing sustained physiological deviation to be evaluated alongside clinically observable behavioral manifestations.
Existing wearables report isolated biomarkers, discrete state classifications, or opaque composite scores. AetherProtocols models the relationship between physiology and behavior as one system.
The relationship exists. Can we measure it?
The biological relationship between physiology and behavior is well established across many clinical conditions. What remains unproven is whether individualized hormonal state can be continuously measured, mathematically modeled, and correlated with clinically observable behavioral manifestations at wearable-device signal quality.
Evaluate whether AetherProtocols can reliably detect the physiological-behavioral relationship within a defined clinical cohort at wearable-device signal quality.
A new class of clinical measurement.
If validated, AetherProtocols introduces a Digital Health Technology that enables continuous measurement of individualized physiological state and correlates that state to clinically observable behavior. Rather than reporting isolated biomarkers or opaque composite scores, the framework provides a measurement clinicians can interpret alongside existing assessments.
Behavioral health
Monitoring for treatment response and state change in psychiatric and neurologic conditions.
Drug safety
Early detection of physiological change in response to pharmacotherapy.
Treatment tracking
Longitudinal assessment of response and adherence in complex chronic conditions.
Clinical trials
Novel digital endpoint construction across multiple therapeutic areas.
Two founders. One substrate.
AetherProtocols is the mathematical framework. Scyla is the biology-native compiler and runtime that executes it. Neither is possible without the other. Both were built here.
Marjorie McCubbins, BSc, MHA candidate
Founder and Chief Executive Officer. Inventor of the AetherProtocols mathematical framework. Four consecutive years of direct bedside care in psychiatric, dementia, end-of-life, and locked behavioral units.
Aislinn Loriel McCubbins
Co-Founder and Chief Operating Officer. Creator of Scyla, the biology-native programming language and compiler on which AetherProtocols executes. Co-inventor on the underlying computational engine.
Jason Alba, MBA, DBA · Co-Founder & Chair of the Board of Directors · Business Strategy · 20+ years Pharma Reg Ops | Robert Michalik, JD, RAC · Regulatory Advisor · 30+ years FDA premarket & SaMD
Active federal tracks: FDA CDER COA Qualification (Section 507) · CDRH Class II De Novo, Pre-Submission Q1 2027
NeXus Neuroinformatics, Inc. · Delaware C-corporation · Wholly-owned operating subsidiary of Nexus Concordat, Inc. · UEI TMUCA7QGRNA7 · marjorie.mccubbins@nexusneurodata.com · nexusneurodata.com